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Keytones-how do they work in your body?

SlimOne
Patient One MediNutritionals
180 gel capsules $58.20

Description
Clinically proven natural ingredients for healthy weight management
* Optimizes breakdown and metabolism of fats
* Maintains youthful hormones linked to peak metabolism
* Promotes desirable and healthy body composition
* Supports lipolysis in conjunction with diet and exercise

Unique Properties
Patient One SlimOne™ unites today’s most dynamic natural ingredients in a breakthrough medinutritional supplement for healthy weight management. With CLA, 7-Keto®, Razberi-K®, and green coffee bean extract, SlimOne supplies advanced nutritional support for desirable body composition, peak metabolic performance, blood sugar support, fat metabolism and more. When used in conjunction with healthy diet and exercise program, Patient One SlimOne helps to maximize weight management results. SlimOne has been carefully formulated to include only gentle, stimulant-free and effective nutrients.

Key Ingredients

CLA:
An omega-6 fatty acid found in grass-fed beef and vegetable oils, CLA (conjugated linoleic acid) is among the most extensively studied weight management nutrients. While its exact mechanisms of action have not been pinpointed, CLA is believed to inhibit the “hunger hormone” leptin, promote lipolysis in white adipose tissue, influence insulin sensitivity, reduce fasting blood glucose and optimize resting metabolic rate. CLA is most commonly associated with lean body mass and healthy body composition.

7-Keto® DHEA
Produced by the adrenal glands, Dehydroepiandrosterone (DHEA) hormone starts to decline around age 30, and has been implicated in metabolic slow-down and age-related weight gain. Restoring DHEA through supplementation is believed to promote a youthful hormonal state that is associated with optimal metabolic rate. 7-Keto DHEA is derived from a plant source that has been purified to match the substance naturally produced in the body. Studies suggest that 7-Keto improves the body’s calorie burning ability at the most basic level by increasing resting metabolic rate—the number of calories burned through regular bodily functions such as breathing. 7-Keto is the weight management metabolite of DHEA–a gentler and safer form that supplies nutritional benefits without influencing testosterone or estrogen levels.

Razberi-K® raspberry ketones
Organic phenolic compounds found in raspberries, ketones are believed to optimize breakdown of fat in the body while promoting peak metabolic function. Some early animal research appears to suggest that raspberry ketones may influence the way lipids are metabolized in fat cells; specifically, raspberry ketones are believed to optimize the breakdown of white adipose tissue. Raspberry ketones have also been found to stimulate the secretion of adiponectin, a hormone that regulates fat storage. Research shows a link between higher levels of adiponectin and lower levels of stored fat.

Green Coffee Bean Extract
Unroasted coffee beans retain their green hue and supply bioactive compounds called chlorogenic acids (CGAs) that are usually destroyed in the coffee bean roasting process. The CGAs found in green coffee beans are believed to promote healthy weight management by influencing sugar metabolism. Research has suggested that CGAs may inhibit the hepatic glucose-6-phosphatase enzyme, thereby modulating glucose production and promoting the blood sugar stability that is associated with healthy weight. SlimOne’s green coffee bean extract is standardized to 50% minimum CGAs.
Research
In one study, 20 men and women took either a CLA supplement (0.6mg) or placebo daily while exercising in standardized 90-minute routines three times weekly. After 12 weeks, researchers reported that body fat was found to be significantly reduced in the CLA group, but not in the placebo group.
In one double-blind, placebo-controlled study designed to evaluate long-term effects of CLA supplementation, 180 volunteers took CLA-free fatty acid (FFA), CLA- triacylglycerol, or placebo over the course of one year. At the study’s end, researchers concluded that supplementation with either the FFA or triacylglycerol form of CLA was associated with significant reductions in body fat mass (BFM) and a tendency towards greater lean body mass.

An early study has suggested that 7-Keto may help with resting metabolic rate of overweight adults. In the study, which included 40 subjects, supplementation with 7-Keto was found to significantly increase resting metabolic rate above basal levels in only seven days. Researchers suggested 7-Keto may benefit overweight individuals with low energy expenditure.

Servings Per Container: 45
Take 4 to 6 capsules daily in divided doses, preferably with a meal, as a dietary supplement or as directed by a qualified health care professional.
Serving Size: 4 Capsules
Amount Per Serving
Calories … 26
Calories from Fat … 25
Total Fat … 2.70g
Saturated Fat … 0.10g
Monounsaturated Fat … 0.30g
Polyunsaturated Fat … 2.30g
Weight Management Proprietary Blend … 3000mg
Conjugated Linoleic Acid 80% oil (CLA); Green Coffee Bean extract (Coffea sp.) (fruit) [Standardized to 50% minimum Chlorogenic acids]; Razberi-K® Raspberry Ketones [4-(4-hydroxyphenyl) butan-2-one]; 7-Keto® DHEA (3-Acetyl-7-oxo-dehydroepiandrosterone)
Other Ingredients: gelatin (capsule), chlorophyll, d-alpha tocopheryl acetate.
This product contains NO egg, fish, peanuts, crustacean shellfish (lobster, crab, or shrimp), soybeans, tree nuts, wheat, yeast, gluten, rice, sugar, or artificial sweeteners, flavors, colors or preservatives.
Razberi-K® is a registered trademark of Integrity Nutraceuticals International, Inc.
7-Keto® is a trademark of InterHealth Nutraceuticals, U.S. Patents No. 5, 585, 371; 6, 153, 606; 6, 489, 313; 7, 553, 829; 7, 199, 116.

References
1. Thom, E, Wadstein J, Gudmundsen O. Conjugated Linoleic Acid Reduces Body Fat in Healthy Exercising Humans. The Journal of International Medical Research. 2001;29:392-396.
2. Kamphuis MMJW, et al. The effect of conjugated linoleic supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects. International Journal of Obesity (2003) 27, 840-847.]
3. Gaullier JM, et al. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am J Clin Nutr 2004;79:1118 –25.
4. Park KS. Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Planta Med. 2010 Oct;76(15):1654-8. doi: 10.1055/s-0030-1249860. Epub 2010 Apr 27.
5. Ong KW, Hsu A, Tan BKH (2012) Chlorogenic Acid Stimulates Glucose Transport in Skeletal Muscle via AMPK Activation: A Contributor to the Beneficial Effects of Coffee on Diabetes. PLoS ONE 7(3): e32718. doi:10.1371/journal.pone.0032718
6. Morimoto C, et al. Anti-obese action of raspberry ketone. Life Sci. 2005 May 27;77(2):194-204. Epub 2005 Feb 25.
7. Henry-Vitrac C, et al. Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract. J Agric Food Chem. 2010 Apr 14;58(7):4141-4.
8. Zenk JL, et al. HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. J Nutr Biochem. 2007 Sep;18(9):629-34.

Do not use if you are pregnant or nursing. Not for use by individuals under the age of 18 years.

Turmeric Curcumin

Turmeric Curcumin 1000mg
Patient One MediNutritionals
60 capsules $21.25

Promotes normal inflammatory response while also supporting joint, immune, gastrointestinal, and cardiovascular function
Promotes immune system function
* Supports brain and joint health
* Promotes healthy liver, gall bladder and digestive function
* Free radical scavenging properties
* Supports cardiovascular function
* Black pepper included for enhanced absorption
Unique Properties
Curcumin, a polyphenol nutrient found in the spice turmeric (Curcuma longa), has beneficial effects for nearly every organ system in the body. Used for its medicinal effects for centuries and extensively studied, Curcumin has been shown to help maintain the bodys normal inflammatory response while also supporting joint, liver, gastrointestinal, and cardiovascular function. To enhance the normally poor bioavailability of curcumin, our potent formula also contains black pepper extract that promotes rapid absorption of nutrients from the gastrointestinal tract.
Key Ingredients
Turmeric (Curcuma longa)
Patient One Turmeric Curcumin combines the benefits of both whole Turmeric root and Turmeric extract (standardized to 95% curcuminoids), along with black pepper extract for enhanced absorption.
Curcumin is the orange pigment in turmeric (the primary ingredient in curry) and has been studied for its effective therapeutic outcomes acting as an antioxidant, anti-inflammatory, antispasmodic, anticoagulant, immuno-modulatory activities and even in wound healing. Research suggests support for joint, eye, GI tract, liver, prostate and nerve health.

Curcumin supports production of B and T cells which is useful for promoting proper immune function. It also supports production of bile and enzymes that digest sugars and fats. This helps to maintain cholesterol levels within normal range. Turmeric supports intestinal flora and the mucus membranes of the body, including those of the digestive tract. As such, it may be beneficial after a course of antibiotics and for those with unbalanced intestinal flora. It also helps protect the stomach against excess acid and is used for its soothing effect on the mucosa of the gut.
Black Pepper Extract (as BioPerine®)
It has been found that the therapeutic effectiveness of curcumin is often limited due to its poor absorption from the GI tract. When taken orally only traces appear in the blood, whereas most of the dose is excreted though the feces. Our formula includes BioPerine®, a patented extract derived from the common black pepper fruit that contains the alkaloid piperine. Black pepper has been shown to enhance the bioavailability and promote absorption of curcumin both in pre-clinical studies and in studies on human volunteers.
Research
* Several studies have illustrated curcumins hepatoprotective effects, leading researchers to suggest its use in protecting the liver from exogenous insults from environmental toxins.
Servings Per Container: 60
Take 1 capsule daily, preferably with a meal, or as directed by a qualified healthcare professional.
Serving Size: 1 capsule
Amount Per Serving
Turmeric Complex Proprietary Blend … 1000mg
Turmeric (Curcuma longa) (root) and Turmeric Extract (Curcuma longa) (root) (Standardized to contain 95% Curcuminoids) 
BioPerine® Black Pepper Extract … 5mg
(Piper nigrum) (fruit) (Standardized to contain 95% piperine)
Other Ingredients: vegetable cellulose (capsule), rice powder, l-leucine
This product is free of milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, sugar, and artificial sweeteners, flavors, colors and preservatives. This product is free of ingredients derived from genetically modified organisms (GMOs).
BioPerine® is a registered trademark and patented product of Sabinsa Corporation

References
* Shoba G, Joy D, Joseph T, et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 1998 May;64(4):353-56. [PMID: 9619120]
* Jagetia GC, Aggarwal BB. “Spicing up” of the immune system by curcumin. J Clin Immunol. 2007 Jan;27(1):19-35. [PMID: 17211725]
* Funk JL, Oyarzo JN, Frye JB, et al. Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. J Nat Prod. 2006 Mar;69(3):351-55. [PMID: 16562833]
* Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009 Jun;14(2):141-53. [PMID: 19594223]
* Ng T, et al. Am J Epidemiol. 2006;164:898-906.
* Sun AY, Wang Q, Simonyi A, et al. Botanical phenolics and brain health. Neuromolecular Med. 2008;10(4):259-74. [PMID: 19191039]
* Neelofar K, Shreaz S, Rimple B, et al. Curcumin as a promising anticandidal of clinical interest. Can J Microbiol. 2011 Mar;57(3):204-10. [PMID: 21358761]
* Epstein J, Docena G, MacDonald TT, et al. Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease. Br J Nutr. 2010 Mar;103(6):824-32. [PMID: 19878610]
* Ukil A, Maity S, Karmakar S, et al. Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis. Br J Pharmacol. 2003 May;139(2):209-18. [PMID: 12770926]
* Holt PR, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: a pilot study. Dig Dis Sci. 2005 Nov;50(11):2191-93. [PMID:16240238]
* Lal B, Kapoor AK, Asthana OP, et al. Efficacy of curcumin in the management of chronic anterior uveitis. Phytother Res. 1999 Jun;13(4):318-22. [PMID: 10404539]
* Xie L, Li XK, Takahara S. Curcumin has bright prospects for the treatment of multiple sclerosis. Int Immunopharmacol . 2011 Mar;11(3):323-30. [20828641]
* Martins CV, da Silva DL, Neres AT, et al. Curcumin as a promising antifungal of clinical interest. J Antimicrob Chemother. 2009 Feb;63(2):337-39. [PMID: 19038979]
* Mythri RB, Harish G, Dubey SK, et al. Glutamoyl diester of the dietary polyphenol curcumin offers improved protection against peroxynitrite-mediated nitrosative stress and damage of brain mitochondria in vitro: implications for Parkinsons disease. Mol Cell Biochem. 2011 Jan;347(1-2):135-43. [PMID: 20972609]
* Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS J . 2009 Sep;11(3):495-510. [PMID: 9619120]
* Goel A, Aggarwal BB. Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutr Cancer. 2010 Oct;62(7):919-30. [PMID: 20924967]
* Choi H, Chun YS, Shin YJ, et al. Curcumin attenuates cytochrome P450 induction in response to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin by ROS- dependently degrading AhR and ARNT. Cancer Sci. 2008 Dec;99(12):2518-24. [PMID: 19018768]
* Zhang, Dong Wei, Chuang Fang Huang, Chang Fu Yang, Ren Zuo Liu, Ji Feng Wang, Jian Zhao Niu, and Dieter Bromme. “Antifibrotic Effects of Curcumin Are Associated with over Expression of Cathespins K and L in Bleomycin Treated Mice and Human Fibroblasts.” Respiratory Research. Respiratory Research, 2011.
* Davis, J. Mark. “Curcumin Effects on Inflammation and Performance Recovery following Eccentric Exercise-induced Muscle Damage.” Am J Physiol Regul Integr Comp Physiol. American Physiological Society, 2007.
* Karlstetter, Marcus, Elena Lippe, Yana Walczak, Chistoph Moehle, Alexander Aslanidis, Myriam Mirza, and Thomas Langmann. “Curcumin Is a Potent Modulator of Microglial Gene Expression and Migration.” Journal of Neuroinflammation. Journal of Neuroinflammation, 2011.
Warnings
If pregnant, nursing, have gall stones or gall bladder disease, consult your healthcare practitioner before taking this product. Individuals taking medication, especially blood thinners or cancer treatment, should discuss potential interactions with their healthcare practitioner. Discontinue use and consult doctor if any adverse reactions occur.