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Understanding Auto Immune disorders

Who understands auto immune disorders and how they affects us and our loved ones?  Here is a brief overview of what it is and a link if you want to research correct information further.

When an intruder invades your body—like a cold virus or bacteria on a thorn that pricks your skin—your immune system protects you. It tries to identify, kill, and eliminate the invaders that might hurt you. But sometimes problems with your immune system cause it to mistake your body’s own healthy cells as invaders and then repeatedly attacks them. This is called an autoimmune disease. (“Autoimmune” means immunity against the self.)

Autoimmune diseases can affect almost any part of the body, including the heart, brain, nerves, muscles, skin, eyes, joints, lungs, kidneys, glands, the digestive tract, and blood vessels. The classic sign of an autoimmune disease is inflammation, which can cause redness, heat, pain, and swelling. How an autoimmune disease affects you depends on what part of the body is targeted. If the disease affects the joints, as in rheumatoid arthritis, you might have joint pain, stiffness, and loss of function. If it affects the thyroid, as in Graves’ disease and thyroiditis, it might cause tiredness, weight gain, and muscle aches. If it attacks the skin, as it does in scleroderma/systemic sclerosis, vitiligo, and systemic lupus erythematosus (SLE), it can cause rashes, blisters, and color changes.

Many autoimmune diseases don’t restrict themselves to one part of the body. For example, SLE can affect the skin, joints, kidneys, heart, nerves, blood vessels, and more. Type 1 diabetes can affect your glands, eyes, kidneys, muscles, and more.

KEY WORDS

Acquired immune system. The part of the immune system that develops as a person grows. It employs antibodies and immune cells to fight harmful substances.

Antibody. A special protein produced by the body’s immune system that recognizes and helps fight infectious agents and other foreign substances that invade the body.

Antigen. A foreign substance that triggers the production of antibodies when it is introduced into the body.

Autoimmune disease. A disease that results when the immune system mistakenly attacks the body’s own tissues.

Corticosteroids. Potent anti-inflammatory hormones that are made naturally in the body or synthetically (man-made) for use as drugs. They are also called glucocorticoids. The most commonly prescribed drug of this type is prednisone.

Diabetes, type 1. A condition in which the immune system destroys insulin-producing cells of the pancreas, making it impossible for the body to use glucose (blood sugar) for energy. Type 1 diabetes usually occurs in children and young adults.

Graves’ disease. An autoimmune disease of the thyroid gland that results in the overproduction of thyroid hormone. This causes such symptoms as nervousness, heat intolerance, heart palpitations, and unexplained weight loss.

Immune system. A complex network of specialized cells and organs that work together to defend the body against attacks by foreign invaders, such as bacteria and viruses.

Thyroiditis. An inflammation of the thyroid gland that causes the gland to become underactive. This results in symptoms such as fatigue, weakness, weight gain, cold intolerance, and muscle aches.

Vitiligo. A disorder in which the immune system destroys pigment-making cells called melanocytes. This results in white patches of skin on different parts of the body.

The National Institutes of Health (NIH)—The Nation’s Medical Research Agency—includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary Federal agency for conducting and supporting basic, clinical, and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH visit:

https://www.niams.nih.gov/Health_Info/

Keytones-how do they work in your body?

SlimOne
Patient One MediNutritionals
180 gel capsules $58.20

Description
Clinically proven natural ingredients for healthy weight management
* Optimizes breakdown and metabolism of fats
* Maintains youthful hormones linked to peak metabolism
* Promotes desirable and healthy body composition
* Supports lipolysis in conjunction with diet and exercise

Unique Properties
Patient One SlimOne™ unites today’s most dynamic natural ingredients in a breakthrough medinutritional supplement for healthy weight management. With CLA, 7-Keto®, Razberi-K®, and green coffee bean extract, SlimOne supplies advanced nutritional support for desirable body composition, peak metabolic performance, blood sugar support, fat metabolism and more. When used in conjunction with healthy diet and exercise program, Patient One SlimOne helps to maximize weight management results. SlimOne has been carefully formulated to include only gentle, stimulant-free and effective nutrients.

Key Ingredients

CLA:
An omega-6 fatty acid found in grass-fed beef and vegetable oils, CLA (conjugated linoleic acid) is among the most extensively studied weight management nutrients. While its exact mechanisms of action have not been pinpointed, CLA is believed to inhibit the “hunger hormone” leptin, promote lipolysis in white adipose tissue, influence insulin sensitivity, reduce fasting blood glucose and optimize resting metabolic rate. CLA is most commonly associated with lean body mass and healthy body composition.

7-Keto® DHEA
Produced by the adrenal glands, Dehydroepiandrosterone (DHEA) hormone starts to decline around age 30, and has been implicated in metabolic slow-down and age-related weight gain. Restoring DHEA through supplementation is believed to promote a youthful hormonal state that is associated with optimal metabolic rate. 7-Keto DHEA is derived from a plant source that has been purified to match the substance naturally produced in the body. Studies suggest that 7-Keto improves the body’s calorie burning ability at the most basic level by increasing resting metabolic rate—the number of calories burned through regular bodily functions such as breathing. 7-Keto is the weight management metabolite of DHEA–a gentler and safer form that supplies nutritional benefits without influencing testosterone or estrogen levels.

Razberi-K® raspberry ketones
Organic phenolic compounds found in raspberries, ketones are believed to optimize breakdown of fat in the body while promoting peak metabolic function. Some early animal research appears to suggest that raspberry ketones may influence the way lipids are metabolized in fat cells; specifically, raspberry ketones are believed to optimize the breakdown of white adipose tissue. Raspberry ketones have also been found to stimulate the secretion of adiponectin, a hormone that regulates fat storage. Research shows a link between higher levels of adiponectin and lower levels of stored fat.

Green Coffee Bean Extract
Unroasted coffee beans retain their green hue and supply bioactive compounds called chlorogenic acids (CGAs) that are usually destroyed in the coffee bean roasting process. The CGAs found in green coffee beans are believed to promote healthy weight management by influencing sugar metabolism. Research has suggested that CGAs may inhibit the hepatic glucose-6-phosphatase enzyme, thereby modulating glucose production and promoting the blood sugar stability that is associated with healthy weight. SlimOne’s green coffee bean extract is standardized to 50% minimum CGAs.
Research
In one study, 20 men and women took either a CLA supplement (0.6mg) or placebo daily while exercising in standardized 90-minute routines three times weekly. After 12 weeks, researchers reported that body fat was found to be significantly reduced in the CLA group, but not in the placebo group.
In one double-blind, placebo-controlled study designed to evaluate long-term effects of CLA supplementation, 180 volunteers took CLA-free fatty acid (FFA), CLA- triacylglycerol, or placebo over the course of one year. At the study’s end, researchers concluded that supplementation with either the FFA or triacylglycerol form of CLA was associated with significant reductions in body fat mass (BFM) and a tendency towards greater lean body mass.

An early study has suggested that 7-Keto may help with resting metabolic rate of overweight adults. In the study, which included 40 subjects, supplementation with 7-Keto was found to significantly increase resting metabolic rate above basal levels in only seven days. Researchers suggested 7-Keto may benefit overweight individuals with low energy expenditure.

Servings Per Container: 45
Take 4 to 6 capsules daily in divided doses, preferably with a meal, as a dietary supplement or as directed by a qualified health care professional.
Serving Size: 4 Capsules
Amount Per Serving
Calories … 26
Calories from Fat … 25
Total Fat … 2.70g
Saturated Fat … 0.10g
Monounsaturated Fat … 0.30g
Polyunsaturated Fat … 2.30g
Weight Management Proprietary Blend … 3000mg
Conjugated Linoleic Acid 80% oil (CLA); Green Coffee Bean extract (Coffea sp.) (fruit) [Standardized to 50% minimum Chlorogenic acids]; Razberi-K® Raspberry Ketones [4-(4-hydroxyphenyl) butan-2-one]; 7-Keto® DHEA (3-Acetyl-7-oxo-dehydroepiandrosterone)
Other Ingredients: gelatin (capsule), chlorophyll, d-alpha tocopheryl acetate.
This product contains NO egg, fish, peanuts, crustacean shellfish (lobster, crab, or shrimp), soybeans, tree nuts, wheat, yeast, gluten, rice, sugar, or artificial sweeteners, flavors, colors or preservatives.
Razberi-K® is a registered trademark of Integrity Nutraceuticals International, Inc.
7-Keto® is a trademark of InterHealth Nutraceuticals, U.S. Patents No. 5, 585, 371; 6, 153, 606; 6, 489, 313; 7, 553, 829; 7, 199, 116.

References
1. Thom, E, Wadstein J, Gudmundsen O. Conjugated Linoleic Acid Reduces Body Fat in Healthy Exercising Humans. The Journal of International Medical Research. 2001;29:392-396.
2. Kamphuis MMJW, et al. The effect of conjugated linoleic supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects. International Journal of Obesity (2003) 27, 840-847.]
3. Gaullier JM, et al. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am J Clin Nutr 2004;79:1118 –25.
4. Park KS. Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Planta Med. 2010 Oct;76(15):1654-8. doi: 10.1055/s-0030-1249860. Epub 2010 Apr 27.
5. Ong KW, Hsu A, Tan BKH (2012) Chlorogenic Acid Stimulates Glucose Transport in Skeletal Muscle via AMPK Activation: A Contributor to the Beneficial Effects of Coffee on Diabetes. PLoS ONE 7(3): e32718. doi:10.1371/journal.pone.0032718
6. Morimoto C, et al. Anti-obese action of raspberry ketone. Life Sci. 2005 May 27;77(2):194-204. Epub 2005 Feb 25.
7. Henry-Vitrac C, et al. Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract. J Agric Food Chem. 2010 Apr 14;58(7):4141-4.
8. Zenk JL, et al. HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. J Nutr Biochem. 2007 Sep;18(9):629-34.

Do not use if you are pregnant or nursing. Not for use by individuals under the age of 18 years.

New to the Gym? No Problem. Check out this STARTER GUIDE – You Can Do It

Lots of people have “gym anxiety”.  You know that feeling that you get when you want to go to the gym, but don’t know what to do, or where to start.  Muscle and Fitness has the answers.

What to do at the Gym

Link to Muscle and Fitness Starter Guide

 

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